GW25-e2405 Myricetin Inhibits Kv1.5 Channel Expressed in HEK 293 Cells
نویسندگان
چکیده
منابع مشابه
Myricetin inhibits Kv 1 . 5 channels in HEK 293 cells
Myricetin (Myr) is a f lavonoid that exerts anti-arrhythmic effects. However, its potential effects on ion channels have remained elusive. The aim of the present study was to investigate the effects of Myr on Kv1.5 channels in HEK293 cells. The current of Kv1.5 channels (Ikur) in HEK293 cells was recorded using the whole-cell patch-clamp technique and the expression of the Kv1.5 protein was mea...
متن کاملAllitridi Inhibits Multiple Cardiac Potassium Channels Expressed in HEK 293 Cells
Allitridi (diallyl trisulfide) is an active compound (volatile oil) from garlic. The previous studies reported that allitridi had anti-arrhythmic effect. The potential ionic mechanisms are, however, not understood. The present study was designed to determine the effects of allitridi on cardiac potassium channels expressed in HEK 293 cells using a whole-cell patch voltage-clamp technique and mut...
متن کاملSingle-Channel Properties of Inositol (1,4,5)-Trisphosphate Receptor Heterologously Expressed in HEK-293 Cells
The inositol (1,4,5)-trisphosphate receptor (InsP3R) mediates Ca2+ release from intracellular stores in response to generation of second messenger InsP3. InsP3R was biochemically purified and cloned, and functional properties of native InsP3-gated Ca2+ channels were extensively studied. However, further studies of InsP3R are obstructed by the lack of a convenient functional assay of expressed I...
متن کاملElectrophysiological properties of mouse and epitope - tagged human cardiac sodium channel Na 1 . 5 expressed in HEK 293 cells
The pore-forming subunit of the cardiac sodium channel, Na 1.5, Background: has been previously found to be mutated in genetically determined arrhythmias. Na 1.5 associates with many proteins that regulate its function and cellular localisation. In order to identify more Na 1.5 interacting proteins, in situ genetically-modified mice with a high-affinity epitope in the sequence of Na 1.5 can be ...
متن کاملBiophysical and Pharmacological Characterization of Nav1.9 Voltage Dependent Sodium Channels Stably Expressed in HEK-293 Cells
The voltage dependent sodium channel Nav1.9, is expressed preferentially in peripheral sensory neurons and has been linked to human genetic pain disorders, which makes it target of interest for the development of new pain therapeutics. However, characterization of Nav1.9 pharmacology has been limited due in part to the historical difficulty of functionally expressing recombinant channels. Here ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2014
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2014.06.191